CD4 and colitis: Colitis induced by the adoptive transfer of naïve CD4+CD45RBhigh T cells into Rag2−/− mice correlated with a reduction in DAB2 levels in CD11b+ DC in the colonic lamina propria upon, suggesting that DAB2 plays a role in keeping the tolerogenic profile in intestinal DCs during homeostasis, and its downregulation may contribute to exacerbated immune responses in inflammatory bowel diseases (IBDs).