As macrophages play a decisive role in atherosclerotic lesion progression, the role of myeloid DAB2 in atherosclerosis has been further tested in LDLR−/− mice reconstituted with myeloid Dab2-deficient bone marrow (BM) from Dab2fl/fl LysM-Cre mice fed with high fat diet (HFD) (32). The gene discussed is DAB2; the disease is atherosclerosis.