In our genome ontology analysis (Table 2), some of the pathways significantly affected by the changes in mRBPs are already recognized as impacted by the pathogenetic process in COPD, such as the expression/activity of the telomerase enzyme and the signaling coordinated by the kinase mTOR (Mammalian Target Of Rapamycin) (91–94); others may indicate so far under recognized disease determinants. This evidence concerns the gene MTOR and chronic obstructive pulmonary disease.