Overall, the TFs putatively binding to the DNA motifs identified with highest enrichment, such as the MEF2 TF family, have pleiotropic functions in cell cycle, cell differentiation, proliferation, apoptosis (87); Interestingly, ARID5A acts both as TF and as RBP according to nuclear or cytoplasmic localization (88); FoxD3 acts as tumor suppressor in lung cancer (89) while HOX genes are overexpressed in non-small cell lung cancer and postulated to act as oncogenes (90). Here, FOXD3 is linked to lung cancer.