ERBB2 and neoplasm: Four i.t. injections of a HER2-targeted oHSV-IL-12 was significantly more effective at inhibiting both day 3 and day 10 tumors than the non-cytokine encoding parental HSV (day 3: 15/22 oHSV-IL-12 vs. 7/20 HSV becoming tumor free; day 10: 3/18 oHSV-IL-12 vs. 1/12 HSV becoming tumor free) (247).