KDR and sarcoma: In one study, i.v. infusion of IL-12 expressing anti-VEGFR2 CAR T cells induced curative regressions in 40–80% of mice in five different tumor models including 10–12-day-old B16F10 melanomas, MCA-205 sarcomas, MC38 colorectal adenocarcinomas, MC17-51 sarcomas or 12–14 days old CT26 colon adenocarcinomas (320).