VV-IL-12 and IL-2 expressing VV (VV-IL-2) exhibited similar inhibition of C6 gliomas (265, 266) However, against AE17 mesotheliomas, VV-IL-12 cured 80% of mice compared to only 20% of mice treated with VV-IL2 (267). This evidence concerns the gene IL2 and glioma.