In an interesting comparison of cytokines, oHSV-IL-12 was more effective at inhibiting flank prostate tumors, TRAMP-c2 and Pr14-2, than oHSV encoding GM-CSF (oHSV-GM-CSF) which was no more effective than non-cytokine encoding oHSV (240). This evidence concerns the gene CSF2 and prostate neoplasm.