CD8A and neoplasm: Indeed, adoptive transfer of tumor-specific CD8+ T cells primed ex vivo in the presence of IL-12 resulted in enhanced antitumor responses (72, 73), increased persistence of infused T cells (73, 74), as well as increased expression of IL-2Rα (CD25], ICOS, OX40, granzyme B, and IFNγ (73).