Several studies disclosed that an ablation of NLRP3 or of the inflammasome components ASC and caspase-1 in mice prevented obesity-induced inflammation in fat depots and liver, ameliorated insulin signaling, increased energy expenditure and prevented liver steatosis as well as pancreatic damage (225, 232). This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.