In line with the mRNA expression of inflammatory cytokines, cells lacking MyD88 were not able to degrade IκB-α, the inhibitor of the transcription factor nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells (NF-κB), upon infection with either C. acnes or L.m. (Figures 4B, C). The gene discussed is NFKBIA; the disease is infection.