Based on the pro-proliferation, anti-apoptosis, anti-infection, and anti-inflammatory effects of PGE2, IL-17A, and IL-22 (12, 15, 17, 19), these cytokines primarily function as tissue-protective cytokines, which facilitate the repair and regeneration of barrier organs, and inhibit septicemia-induced morbidity and mortality. This evidence concerns the gene IL22 and infection.