LEP and obesity due to melanocortin 4 receptor deficiency: Furthermore, propionate production would also be beneficial in people that suffer of obesity since it inhibits cholesterol synthesis at the liver, regulates lipogenesis in adipose tissue (Ríos-Covián et al., 2016; Tsai et al., 2019) and regulates appetite through the expression of leptin, PYY and GLP-1 (Chambers et al., 2015).