Therefore, we aimed to investigate the association between Lp-PLA2 and plaque vulnerability in transient ischemic attack (TIA) patients with middle cerebral artery stenoses (MCAs) and explored whether Lp-PLA2 could be a potential diagnostic biomarker for plaque vulnerability in intracranial atherosclerotic artery. The gene discussed is PLA2G7; the disease is transient ischemic attack.