Based on the high correlation between ADAMTS13 with sVAP1 detected only in MS patients with CMBs, and on low ADAMTS13 (14) and high sVAP1 plasma levels (20), previously observed in the same patients, it is intriguing to speculate that the ADAMTS13 function could be correlated to reactive oxygen species (39) produced by VAP1, an inflammatory adhesion molecule endowed with enzymatic properties (40). The gene discussed is AOC3; the disease is myeloid sarcoma.