Lei Yu et al. demonstrate that DNA methylation levels in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 are associated with greater odds for pathological AD by examining 28 reported AD loci discovered from recent GWAS reports on AD, which indicate that the change of DNA methylation of AD risk genes contribute to the etiology of AD (45). This evidence concerns the gene HLA-DRB5 and Alzheimer disease.