Hypoxia increases PGF expression in human myocardium (Torry et al., 2009), and pathological cardiac conditions such as ischemic cardiomyopathy or acute myocardial infarction result in elevated plasma levels of PGF (Iwama et al., 2006; Nakamura et al., 2006). This evidence concerns the gene PGF and ischemic cardiomyopathy.