As nesfatin-1 and irisin-1 play many vital roles in glucose homeostasis as a regulator of glucose levels and energy expenditure, taking advantage of our results, and considering these beneficial effects, exercise training may be a safe and accessible strategy for most patients with metabolic syndrome to improve the effect of irisin-1 and nesfatin-1 on metabolic factors. Here, NUCB2 is linked to metabolic syndrome.