NUCB2 and metabolic syndrome: Therefore, this study meant to examine two hypotheses: (i) whether different training regimens including aerobic, resistance, and a combination of aerobic and resistance, alter the serum level of irisin-1, nesfatin-1 and HOMA-IR, and (ii) whether changes in the serum irisin-1, nesfatin-1 levels, and HOMA-IR are associated with changes in other metabolic and anthropometric parameters in women with metabolic syndrome.