CPQ and Cognitive impairment: The aminopeptidase is expressed in areas of the brain associated with cognition (Fernando et al., 2005; Albiston et al., 2007; Albiston et al., 2011), and the observation that Ang IV improves memory and learning has attracted attention to the aminopeptidase IRAP as a potential macromolecular target for drugs for treatment of cognitive disorders (Wolfe, 2002; Gard, 2008; Wright and Harding, 2008; Hallberg, 2009).