Moreover, AQP1 and AQP3 protein expression was highest in poorly differentiated tumors (Direito et al., 2017; Zou et al., 2019), whereas AQP5 is more expressed in moderately differentiated tumors (Direito et al., 2017), suggesting that AQPs are associated with tumor aggressiveness. The gene discussed is AQP1; the disease is neoplasm.