Upregulation of Kv11.1 expression was associated with advanced tumor grade and high expression of Ki67 proliferative marker (Lastraioli et al., 2015b), whereas TRPV6, TRPM8 and AQP1/AQP3 channels were positively correlated with tumor stages III and IV and large tumor size (Yee et al., 2014; Du et al., 2018; Liu et al., 2018; Song et al., 2018; Zou et al., 2019). This evidence concerns the gene MKI67 and neoplasm.