CFTR and neoplasm: Among all the studied channels, only CFTR has lower expression in cancer cell lines compared to normal cells (Singh et al., 2007), while Kv1.3, Kv7.1, and TASK-1 were downregulated in PDAC tissue compared to healthy tissue (Brevet et al., 2009; Williams et al., 2013; Tawfik et al., 2020), suggesting a protective role and tumor suppressive function for these channels.