The role of ASIC1 and ASIC3 was further confirmed in-vivo, where a xenograft mouse model injected with BxPC-3 cells with a stable knockdown of ASIC1 and ASIC3 showed a significant decrease in lung and liver metastasis, but no obvious effect on tumor growth (Zhu et al., 2017). Here, ASIC3 is linked to neoplasm.