AKT1 and endometrial cancer: VP inhibited GAB2-dependent PI3K/AKT signaling in endometrial cancer cells by inhibiting YAP and TAZ, downregulated p-mTOR and its target genes p-4EBP1 and p-S6 in endometrial and liver cancer cells, and inhibited the growth of the xenografts (Wang et al., 2015a; Zhou Y. et al., 2019).