CCN1 and colonic neoplasm: In addition, the YAP-TEAD complex promotes transcription of the pro-angiogenic Cysteine-Rich Angiogenic Inducer 61 (CYR61) and the immunosuppressive programmed cell death-Ligand 1 (PD-L1) in colon cancer tissues and cell lines (Xie et al., 2019; Zhang et al., 2019).