It also inhibited the expression of tumor stem-associated protein SOX2, CD44, and CD133 in drug-resistant breast cancer cells and upregulated anoikis-induced cell death in drug-resistant breast cancer and cholangiocarcinoma cell lines (Li et al., 2019; Sugiura et al., 2019; Wu et al., 2020). Here, SOX2 is linked to breast carcinoma.