In patients with dedifferentiated liposarcoma (DDLS), the conversion of Tissue Inhibitors Of Metalloproteinase 4 (TIMP-4) to TIMP-1 is associated with poor prognosis.TIMP-1 knockout, TIMP-4 overexpressing, or VP-mediated YAP/TAZ blockade can inhibit the proliferation and migration of DDLS cells (Madhu et al., 2019). Here, TIMP4 is linked to liposarcoma.