For example, two schizophrenia-related landmark studies, showed that the activation of the Gq-protein cascade through the synthetic receptor hM3Dq specifically in parvalbumin-positive (PV) interneurons of the dorsal CA1-region of the hippocampus could improve schizophrenia-related physiological and behavioral deficits in a mouse model carrying a human genetic risk factor of schizophrenia (Lgdel-hemideletion) (Marissal et al., 2018; Mukherjee et al., 2019). This evidence concerns the gene PVALB and schizophrenia.