For instance, changes in ECM composition (Logun et al., 2019) or decreased oxygen tension on the TME is related to higher CD133 expression (Platet et al., 2007; Soeda et al., 2009; Musah-Eroje and Watson, 2019) and faster expansion and retained undifferentiation in CD133+ gliomas cells. This evidence concerns the gene PROM1 and central nervous system cancer.