Furthermore, L1CAM function in GBM cell migration was determined by the same group; ADAM10 would cleavage L1CAM ectodomain, which then would activate EGFR and integrins (FAK-mediated process) to promote glioma CSC migration (Bao et al., 2008; Yang et al., 2011). This evidence concerns the gene L1CAM and central nervous system cancer.