LAMB2 and central nervous system cancer: Integrin α6β1is also present in ECs from the perivascular glioma niche; upon laminin-binding, it has been shown to inhibit proapoptotic signals mediated by TNFR1, through NF-κB, by increasing cFLIP and XIAP, and promote EC growth (Figure 2) (Huang et al., 2012).