In addition to the genes mentioned above, mutations in charged multivesicular body protein 2B (CHMP2B) (Skibinski et al., 2005), in the ESCRT-III complex, and C9ORF72, which colocalizes with RAB proteins, are linked to defects in endosomal trafficking in FTD (Farg et al., 2014). This evidence concerns the gene CHMP2B and frontotemporal dementia.