Of notice, by using the monoclonal Tet Off-tau RD-YFP cell line system, the authors found that tau RD strains derived from the brain homogenates from 29 patients with AD, Argyrophilic grain disease (AGD), PiD, and PSP displayed distinctive strain compositions across the diseases (Sanders et al., 2014). Here, MAPT is linked to argyrophilic grain disease.