Aside from AD/tauopathies, the fact that NFTs are also found in brains of subjects with Niemann-Pick type C (NPC), a lysosomal storage disease resulting from lysosomal function defects, suggests endolysosomal failure might be inducing tau aggregation and tangle build-up in the brain (Wang and Mandelkow, 2012). Here, MAPT is linked to Alzheimer disease.