Furthermore, many chemokine receptors like CCR4, CCL14, XCR1 along with the adaptor molecules CRKII and ELMO1 were downregulated during initial and mid stages of infection, and in contrast, some G protein signaling molecules such as GNAI, GNB1, FAK and FAK2 were upregulated in infected fish (Fig. 5B). The gene discussed is PTK2; the disease is infection.