We also note that, while there are several models of skeletal neurofibromatosis, each generated using different cre lines and with different features, several of the MEKK2 or ponatinib-dependent endpoints examined here, such as the cortical porosity/endocortical pitting phenotype, are shared across several models, including Nf1fl/fl;Prx-Cre26, Nf1fl/fl;Col2-Cre27, and Nf1fl/fl;Osx-Cre32 mice, providing support for these findings having relevance beyond the specific Dmp1-Cre based model utilized here. Here, DMP1 is linked to neurofibromatosis.