SEMA4C and colorectal carcinoma: The results showed that gene sets related to EMT (normalized enrichment score [NES] = 2.58), hedgehog signaling (NES = 2.23), Wnt/β-catenin signaling (NES = 2.01), angiogenesis (NES = 1.78), TGF-β signaling (NES = 1.66), and Notch signaling (NES = 1.62) were significantly enriched in CRC patients with high SEMA4C expression (P < 0.05; Figure 5).