FARDIN hypoxia signaling, MENSE hypoxia signaling, MIZUKAMI hypoxia signaling, PID-HIF1-THPATHWAY, and PID-HIF2 PATHWAY pathways were all predicted activation of hypoxia- and HIF-related signaling pathways in the PBRM1mut group of ccRCC patients. The gene discussed is MTA2; the disease is nonpapillary renal cell carcinoma.