However, PBRM1MUT ccRCC tissues showed lower proportions of CD8+ T cells (P=0.004) and activated CD4+ memory T cells (P=0.403), and significantly higher proportion of resting mast cells (P<0.001) compared to the PBRM1WT ccRCC tissues (Figure 2B), and other immune cell types in the ccRCC TME exhibited weak correlation with the PBRM1MUT genotype. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.