We analyzed the gene expression and mutation data of 178 ccRCC patients in the TCGA KIRC database to evaluate the relationship between mutations in VHL, PBRM1, BAP1, and SETD2 genes in the ccRCC tissues and the infiltration of 22 different immune cell types in the TME. The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.