As shown in Figure 8C, CCL5high ccRCC patients showed significant enrichment in immune-related signaling pathways, including inflammatory signaling (P=0.0103), IFN-γ signaling (P=0.0103), IFN-α signaling (P=0.002), IL-6-JAK-STAT3 (P=0.0018), and TNF-α-NF-ΚB signaling (P=0.0103). This evidence concerns the gene IL6 and nonpapillary renal cell carcinoma.