SETD2 and neoplasm: Furthermore, GSEA showed activation of FARDIN hypoxia signaling (red), MENSE hypoxia signaling (green), MIZUKAMI hypoxia signaling (green), PID-HIF1-THPATHWAY (purple), and PID-HIF2 PATHWAY (blue) in the PBRM1MUT ccRCC tumor samples (Figure 3F).