In the current study we intend to integrate the mvMR and MR-BMA approach to identify and prioritize the most likely causal risk factors for AD, the risk factors included in the current study are body mass index (BMI), type 2 diabetes (T2D), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), total cholesterol, fasting glucose (FG), fasting insulin (FI), currently tobacco smoking, and years of schooling. Here, INS is linked to Alzheimer disease.