In a first in human, phase I dose-escalation study, the oral competitive A2AR inhibitor ciforadenant (CPI-444) was evaluated as monotherapy and in combination with atezolizumab in patients with advanced refractory cancers.32 Among patients with treatment-refractory mRCC, ciforadenant demonstrated encouraging efficacy, and disease control lasting at least 6 months was seen in 39% of patients treated with the combination. This evidence concerns the gene ADORA2A and cancer.