CTLA4 and neoplasm: figure 5C, D demonstrated that non-expanded autologous TALs were able to significantly delay 998-PDX1-sph tumor growth in mice as compared with the non-treatment group. Dual blockade with anti-PD1/CTLA4 antibodies further improved tumor control by the autologous TALs, though the response was less robust and of shorter duration than that observed for 099-CL-Luc tumors (figure 5B).