When gene expression levels were queried for gene set enrichment (GSEAs) against the ImmuneSig database [28], we found the following differences in immunological pathways between non-progressors and progressors: First, congruently with the observations in peripheral blood, non-progressors displayed a reduction of GSEAs related with suppressive activity of FoxP3 Treg cells, but an enrichment in signatures related to stimulated CD8 T cells (Fig. 5f and h), which suggest an increased effector activity in the tumor tissue. This evidence concerns the gene CD8A and neoplasm.