VEGF-A (Vascular Endothelial Growth Factor-A), the main soluble factor responsible for tumor angiogenesis, is also involved in creating an immunosuppressive tumor microenvironment: it prevents dendritic cell (DC) precursors from evolving into mature antigen-presenting DCs and promotes the development of tumor-associated macrophages [13, 14]. The gene discussed is VEGFA; the disease is neoplasm.