In contrast, the concentration of IgM and IgG expressions in recipient circulating blood revealed a trend of decrease at 2 weeks after transplantation in the ASCs/ALS/CsA treatment group, consistent with increasing the percentage of CD45Ra+/Foxp3+ B cells expression in the circulating blood, and were restored toward normal at 4 weeks after transplantation. Here, CD40LG is linked to amyotrophic lateral sclerosis.