Interestingly, Purow et al. showed that Notch1 transcriptionally regulates EGFR, which is proved to be highly increased in GBM, through TP53 [26], Consistently, transcription of Notch signaling mediator genes are significantly overexpressed in the molecular subset of GBM with EGFR amplification [27]. The gene discussed is EGFR; the disease is glioblastoma.