In BC-blood, high CYP27A1 expression was also significantly associated with larger tumor size (P = 0.02) and patients with high CYP27A1 tumors were more likely to have received chemotherapy (OR = 1.51, 95%CI = 1.07–2.14) and less likely to have received endocrine treatment (OR = 0.62, 95%CI = 0.45–0.87). The gene discussed is CYP27A1; the disease is breast cancer.