Nelson et al. have further demonstrated that the tumor growth-enhancing effect of a high cholesterol diet in mice is attributable to 27HC and not directly to cholesterol since the pro-tumorigenic effects of 27HC and a high-cholesterol diet in the mice were abrogated by genetic and pharmacological inhibition of CYP27A1 [12, 27]. Here, CYP27A1 is linked to neoplasm.