The total number of phosphatidylserine (PS, annexin-V binding for most microvesicles)-and CD63 (exosome)-carrying EVs, EVs from glomerular cells (juxtaglomerular cells, podocytes) and cells of the proximal tubule, thick loop of Henle, distal tubule, collecting duct, and renal pelvis significantly differed between PH1 patients without NC or KS and patients with NC or KS (Table 2). This evidence concerns the gene CD63 and primary hyperoxaluria type 1.