In this study, immunohistochemistry revealed that the proliferation index of Ki-67 in secondary tumors was higher than that in primary tumors, but radiography revealed that primary tumors were more destructive than secondary tumors, indicating that the increase in the Ki-67 index could not explain the invasiveness and bone destruction of those lesions but could help explain its ability to sustain growth and expansion [14]. Here, MKI67 is linked to secondary neoplasm.