CD4 and systemic lupus erythematosus: Figure 5 shows a higher production of IFNγ by stimulating different subsets of PBMCs with ISG15 containing NETs from SLE patients, compared with NETs of healthy donors, lacking such post-translational modification, including CD4+ lymphocytes (Fig. 4f), CD8+ lymphocytes (Fig. 4g), and NK CD56+ lymphocytes (Fig. 4h).