NETs containing ISG15 from SLE patients induce IFNγ production from diverse cellular subsets: To address the functional impact of ISG15 on the NETs from lupus patients, the production of IFNγ in subsets of T lymphocytes (CD4+ and CD8+) and NK cells was evaluated by multiparametric flow cytometry. Here, ISG15 is linked to systemic lupus erythematosus.