Epidermal growth factor receptor variant III (EGFRvIII) [13], human epidermal growth factor 2 (HER2) [14] and erythropoietin-producing hepatocellular carcinoma A2 (EphA2) [15] were also developed as major targets for their overexpression in GBM but not in healthy brain tissues. This evidence concerns the gene EPHA2 and glioblastoma.