ERBB2 and glioblastoma: As for GBM, investigators at Baylor College of Medicine have conducted a clinical trial (NCT01109095) to evaluate the safety and efficacy of HER2-specific CARs using virus-specific T cells (CAR-VSTs) [59]; previous studies have shown that virus engineered cytotoxic T cells demonstrate better persistence and T cell expansion through appropriate co-stimulatory signaling activation [64].