BRF2 and esophageal squamous cell carcinoma: Interestingly, BRF2 expression is an independent prognostic factor for overall survival (p = 0.014) and biomarker for progression-free survival (p = 0.014) for patients with esophageal squamous cell carcinoma (ESCC) undergoing three-field lymph-node dissection (3FLND) treatment [25].