BRF2 and breast cancer: However, we were able to query the metastatic data sets in the cBioPortal [26] for BRF2 alterations by age of primary breast cancer diagnosis grouped in 5-year intervals: (Fig. 8c) 35 < x < 40, (Fig. 8d) 40 < x < 45, (Fig. 8e) 46 < x < 50, (Fig. 8f) 50 < x < 55, (Fig. 8g) and 55 < x < 60.