BRF2 and invasive breast carcinoma: In the cBioPortal Breast Invasive Carcinoma (TGCA, Firehose Legacy) [28] data set, MYC alterations correlated with a decrease in overall survival, p = 0.0918 (Fig. 8f) and co-occurring MYC and BRF2 alterations significantly decreased overall survival, p = 5.299e-3 (Fig. 8g).