Using the same stringent threshold criteria used in the outlier analysis for BRF2 (Fig. 1a) an outlier analysis of TFIIB demonstrated TFIIB overexpression in 5 of 67 (0.07%) and TFIIB underexpression in 17 of 67 (25%) breast cancer data sets analyzed (Fig. 1b). Here, GTF2B is linked to breast cancer.