Expression analysis of DHODH and UMPS in TCGA and GSE15434 datasets showed no significant differences in the expression of these genes in AML patients depending on the cytogenetics or mutational status in CEBPA, FLT3 or NPM1 (Supplementary Fig. 1A), and the expression of both DHODH and UMPS genes was inversely correlated with the expression of ITGAM (CD11b) in TCGA and OHSU BeatAML datasets (Supplementary Fig. 1B). Here, FLT3 is linked to acute myeloid leukemia.