ITGAM and leukemia: In one patient sample (Pt 14: FAB-M2, normal karyotype, FLT3wt NPM1wt, primary refractory), the addition of AICAr in concentrations that reduced the number of leukemia cells resulted in a pronounced increase in the expression of markers CD11b and CD64, as well as an increase in percentage of CD45high cells, suggesting the differentiation of blasts to more mature forms (Fig. 2a & b).