As shown in Fig. 4e, an increase in the expression of genes associated with macrophage differentiation (e.g. CSF1R, SOCS3, CD163, CCR1, CCR7...) followed by a decrease in the expression of markers of immature cells (CD34 and KIT/CD117) or monocytes (CCR2) was observed in both primary AML cells and U937 cell line. The gene discussed is CCR2; the disease is acute myeloid leukemia.