The success of IDH inhibitors invigorated interest in the role of metabolism in differentiation so that several new enzymes have been reported as possible targets for differentiation of AML, including methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2) [9], dihydroorotate dehydrogenase (DHODH) [10] and lysine-specific demethylases [11]. This evidence concerns the gene IDH2 and acute myeloid leukemia.