The success of IDH inhibitors invigorated interest in the role of metabolism in differentiation so that several new enzymes have been reported as possible targets for differentiation of AML, including methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2) [9], dihydroorotate dehydrogenase (DHODH) [10] and lysine-specific demethylases [11]. Here, DHODH is linked to acute myeloid leukemia.