In addition, based on the ceRNA regulatory network directly associated with HTN, insulin signaling pathway was modulated by mRNAs PPP1R3C, PPKAR2B and AKT3, miRNA hsa-miR-107, and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG. MiRNA hsa-miR-107, as the hub in this network, was reported to be overexpressed in gastric carcinoma and promote tumor growth and survival [39]. Here, AKT3 is linked to hypertensive disorder.