Insulin signaling pathway was screened to directly associate with HTN and was modulated by mRNAs PPP1R3C, PPKAR2B and AKT3, miRNA has-miR-107, and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG. This evidence concerns the gene AKT3 and hypertensive disorder.