Finally, the ceRNA regulatory network directly associated with HTN revealed that insulin signaling pathway was directly related to HTN and found the pathway was regulated by 3 mRNAs (PPP1R3C, PPKAR2B and AKT3), 1 miRNA (has-miR-107) and 3 lncRNAs (SNHG14, TUG1, ZNF252P-AS1 and MIR503HG). The gene discussed is INS; the disease is hypertensive disorder.