EGF and hepatocellular carcinoma: To further understand the role of EGF with respect to proliferation and the sorafenib/CuB‐mediated molecular mechanism in HCC, as shown in Figs 4C and 5A,B, EGF‐enhanced cell viabilities and colony formation abilities were identified, similar to a previous study suggesting that the EGF receptor showed a correlation with proliferating activity in HCC [37].