In addition, hypermethylated NEUROG1, RASSF1A, RASSF2A, SDC2, SEPT9, TAC1, and THBD genes were detected in early stage CRC, hypermethylation of ALX4, FBN2, HLTF, P16, TMEFF1, and VIM genes was associated with poor prognosis, and hypermethylated P16 and TFPI2 genes were related to recurrence of CRC [14]. The gene discussed is FBN2; the disease is colorectal carcinoma.