Schnitzler’s syndrome (SchS) is a rare autoinflammatory disease described by L. Schnitzler in 1972 [1] characterized by urticarial rash and monoclonal gammopathy, usually Immunoglobulin (Ig) M or, rarely, IgG, associated with fever, joints and bones pain, enlarged lymph nodes, leukocytosis, and systemic inflammation (usually erythrosedimentation rate (ESR) and C-reactive protein (CRP) elevation) [2]. The gene discussed is CRP; the disease is monoclonal gammopathy.