TGFB1 and neoplasm: M1 macrophages with elevated HLA-DR produce proinflammatory cytokines, such as IL-1β and tumor necrosis factor (TNF), to kill tumors, while M2 macrophages with increased scavenger receptor (CD163) and mannose receptor (MRC1, CD206) to release immunosuppressive molecules, such as IL-10 and TGF-β, to promote tumor growth [9–11].