To further clarify the heterogeneity of the M1/M2 patterns of the MPE-Mφ, we collected MPE-Mφ from advanced lung adenocarcinoma patients (N = 60), and the gene expression of six M1 markers (HLA-DRA, IL-1β, IL-6, CXCL10, TNF, and CD80), five M2 markers (CD163, CCL18, MRC1, TGF-β1, and IL-10) and two pan-macrophage markers (CSF1R and PTPRC) were characterized. Here, CD163 is linked to lung adenocarcinoma.