By contrast, our findings found that the MPE-Mφ may be different from the TAMs in lung tumor tissues and showed a dual tendency in their M1/M2 patterns, which is similar to the data for the TAMs in pancreatic ductal adenocarcinoma (PDAC) that expressed both M1 (HLA-DR, IL-1β and TNF-α) and M2 (CD163 and IL-10) markers [35]. This evidence concerns the gene TNF and pancreatic ductal adenocarcinoma.