Taken together, the results obtained in the present study suggest that IL-1β and IL-8 are involved in the early response against bacterial pathogens in pacu, which, during bacterial infections, takes less then 12 hours to initiate, and since the inflammatory process occurs as a cytokine activation cascade, after this period, their expression decreases to physiological levels and other proteins may take place in the maintenance of the inflammatory process (Secombes et al., 2011). Here, CXCL8 is linked to bacterial infectious disease.