Also, similarly to the researchers who developed the TIC-DUX4 mouse, Jones and Jones (2018) crossed their transgenic mouse with several Cre-carrying lines to optimize the induction, and the same skeletal muscle-specific, tamoxifen-inducible mouse (McCarthy et al., 2012) produced the best FSHD model. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.