Currently, pituitary dysfunction is considered to be the most common complication of CRT, and the largest long‐term study of children treated with chemotherapy and radiotherapy (748 participants treated with CRT with a mean follow‐up time of 27.3 years) showed that the cumulative incidence of GH, TSH, ACTH and gonadotropin deficiency at 40 years of age was 72.4%, 11.6%, 5.2% and 24.4%, respectively.26 The gene discussed is GH1; the disease is Gonadotropin deficiency.