The pharmacological activities of natural plants and their isolates affect the pathogenesis of hypertension by modulating several parameters like endothelial function, ROS production, pro-inflammatory signaling, platelet activation, opening and closing of different ion channels, ACE inhibition, gene expression etc. Surely, the herbal remedies will be of more attention in the coming time, as they possessing a broad spectrum of achievement, after needful clinical and experimental studies. This evidence concerns the gene ACE and Hypertension.