Folic acid, transferrin etc. were widely explored as affinity ligands for targeting many tumors cells.[76, 77, 78] For example, recently, researcher developed a gold nanocarrier loaded with drug Aurimmune CYT‐6091 and functionalized with tumor necrosis factor alpha (TNF‐α) using polyethylene glycol (PEG) linker for treating lung cancer. This evidence concerns the gene TNF and lung cancer.