developed a polymeric nanoparticle system comprised of PEI‐PEG copolymer for the delivery of Akt1 shRNA in lung cancer cells.[157] Both service and internally anionic polypropylenimine tetrahexacontaamine (PPI) and polyamidoamine (PAMAM) dendrimers were successfully used for the delivery of nucleic acids into cancer cells.[158, 159, 160] It was found that dendrimers and additional caging of resulting nanoplexes protected nucleic acids from degradation and effectively delivered genetic material inside cancer cells. The gene discussed is AKT1; the disease is cancer.