Plasma levels of t-PA were significantly higher in patients with AVSc [median = 2063.10 pg/mL (IQR 1403.54.89–2731.46 pg/mL)] than in non-AVSc counterparts [median = 1403.17 pg/mL (IQR percentile 1026.50–1976.95 pg/mL, p < 0.001)] (Figure 3).The Spearman rank correlation analysis showed that plasma t-PA level correlated positively with age, status of coronary artery disease, as well as levels of CRP, γGT and triglyceride while it was inversely related to HDL-C levels and eGFR (Supplementary Table 1). Here, CRP is linked to coronary artery disorder.