INS and Hyperinsulinemia: The development of liver steatosis and insulin resistance are usually strongly associated.[1, 2, 3] Besides, increased CD36 expression in the livers has been associated with insulin resistance and hyperinsulinemia,[37] while liver‐specific ablation of CD36 improves insulin sensitivity in HFD‐fed mice.[38] Therefore, we speculate that overexpression of NR2F6 might disrupt glucose homeostasis in lean mice, while knockdown of NR2F6 could improve whole‐body glucose homeostasis in obese mice.