The lethality of TNF in tumor‐bearing mice is mitigated by the application of anti‐TNFR1 antibody, thus facilitating the design of a safe TNF‐based antitumor therapeutic strategy.[57] Here, we showed in a mouse model that anti‐TNFR1 antibody significantly suppressed liver tumor formation and distant metastasis to the lungs. Here, TNFRSF1A is linked to neoplasm.