Using an EV education mouse model[6] comprising the repeated EV injections prior to the implantation of HCC tumor seeds in the liver (Figure 1B), we observed that compared to mice treated with MIHA‐EVs, mice administered with MHCC97L‐EVs showed enhanced growth of the primary tumor in the liver (Figure 1C,D) and increased distant metastasis to the lungs (Figure 1E). This evidence concerns the gene XIAP and neoplasm.