CD274 and hepatocellular carcinoma: EV miR‐1247‐3p released by HCC cells has been shown to activate CAFs to foster lung metastasis.[34] A recent study reported the effect of EV miR‐23a‐3p on HCC cells in attenuating antitumor immunity by upregulating PD‐L1 expression in macrophages.[35] In addition to containing oncogenic miRNAs, EVs can also contain tumor suppressor miRNAs.