TP53 and central nervous system cancer: In order to delineate the intratumoral hierarchy of OPC‐originated gliomas, we resorted to a genetic mouse model (referred to as CKO_NG2‐CreER, Figure 1A) and performed droplet‐based single‐cell RNA sequencing (scRNA‐seq).[8] In the CKO_NG2‐CreER model, tumor suppressors Trp53 and NF1 were specifically inactivated in adult OPCs using a temporally controllable OPC‐specific NG2‐CreER transgene.