IGF1R and neoplasm: As the tumor cells were derived directly from the patient (Figure 6L) with minimal exposure to in vitro conditions (less than 12 h) and electroporation delivered vectors into all tumor cell types equally, this patient‐derived xenograft (PDX) model offered a unique opportunity to evaluate the effects of IGF1R deprivation on OPC‐like and non‐OPC‐like cells in the same tumor, which helped to address the question whether distinct subpopulation of in the same tumor possessed the same susceptibility to IGF1R targeting.