NF1 and central nervous system cancer: It is well known that NSCs can give rise to OPCs throughout life.[35] Accordingly, knocking out of Trp53 and NF1 directly in NSCs, as in OPCs, can efficiently generate high‐grade gliomas.[4, 7] Given that adult NSCs and OPCs are in the same development hierarchy during gliomagenesis but possess distinct cell identities, a genetic model using adult NSCs as the glioma cell‐of‐mutation will help to address this question.