Of note, we found that in IGF1R‐knockout tumor OPCs, PDGFRα protein lever was significantly decreased (Figure 7K), raising the interesting possibility that the interaction between IGF1R and PDGFRα may help to stabilize PDGFRα proteins and facilitate the PDGFRα‐mediated signaling, and therefore inactivation of IGF1R by degradation may have more profound effects than merely blocking its kinase activity. This evidence concerns the gene IGF1R and neoplasm.