PURPL, which is transactivated by p53, reduces the level of p53 protein by preventing MYBBP1A‐mediated p53 stabilization, and overexpression of PURPL promotes growth of colorectal cancer.[12] Here, we characterize a novel p53‐lnc‐Ip53 negative feedback circuit and elucidate its biological significance in cell cycle progression and apoptosis, as well as in tumor development and chemoresistance. This evidence concerns the gene TP53 and neoplasm.