PURPL and neoplasm: PURPL, which is transactivated by p53, reduces the level of p53 protein by preventing MYBBP1A‐mediated p53 stabilization, and overexpression of PURPL promotes growth of colorectal cancer.[12] Here, we characterize a novel p53‐lnc‐Ip53 negative feedback circuit and elucidate its biological significance in cell cycle progression and apoptosis, as well as in tumor development and chemoresistance.